Welcome to the COOL lab at Oregon Health & Science University. We are dedicated to the advancement of biomedical imaging techniques in order to improve the diagnosis and treatment of eye diseases.

Please see the careers tab for opportunities at the COOL Lab!
Congratulations to Dr. David Huang, who has been promoted to Associate Director of Casey Eye Institute!
Congratulations to Dr. Yali Jia, who has been chosen to represent imaging on the CEI Research Advisory Council!


Dr. Priscilla Q. Vu 


Priscilla Q. Vu, MD, MS, is currently the Cornea, External Eye Disease & Refractive Surgery Fellow at Casey Eye Institute. She graduated from medical school and ophthalmology residency at the University of California, Irvine. Her research interests are in clinical and surgical ophthalmology as well as anterior segment imaging.

Shanjida Khan 


Shanjida is a PhD student in the Biomedical Engineering department at OHSU. She earned her BSc degree in Physics from Drew University in 2020. Her current research interest lies in the area of optical imaging

Dr. Karine Bojikian 

Heed Society Glaucoma Fellow at the OHSU Casey Eye Institute


Dr. Bojikian completed her Ophthalmology residency at the University of Washington in Seattle and earned her medical degree and PhD from the Federal University of Sao Paulo. She has participated in several clinical research projects in glaucoma, authoring/co‐authoring over 50 abstracts and peer‐reviewed publications. Her current research investigations encompass the applications of OCT Angiography in the diagnosis and disease progression monitoring in glaucoma, and the effects of cataract surgery in glaucoma patients.

Keke Liu

Medical student at the University of Hawaii John A. Burns School of Medicine - 1yr research fellow


Keke earned his BS in biomedical engineering at University of Miami. His research interests include OCT and OCTA imaging in glaucoma and retinal diseases.


Yali Jia, PhD and John Morrison, MD Received NIH R01 Grant for visible-light OCT angiography, velocimetry, and oximetry for characterizing retinal vascular alterations in glaucoma (2020-2023)


This project will develop advanced technology to image retinal capillaries and measure capillary blood flow and oxygen content. This may provide an early indicator of glaucoma progression and help study a potential cause of increased susceptibility to intraocular pressure in glaucoma patients.

Future Vision Foundation selects Dr. David Huang for 2019 Future Vision award

Dr. Huang is the co-inventor of Optical Coherence Tomography (OCT), the most commonly used ophthalmic imaging technology at 30 million procedures per year. His seminal article on OTC has been cited over 13,000 times. Dr. Huang’s work is recognized as one of the most influential in the history of Ophthalmology.




The mission of the Center for Ophthalmic Optics and Lasers (COOL) is to conserve, improve and restore vision through advances in laser and optical technology.


The Center for Ophthalmic Optics and Lasers (COOL) at the Casey Eye Institute, Oregon Health & Science University is an interdisciplinary research center that focuses on improving the diagnosis and treatment of eye diseases through advances in laser and optical technology.  David Huang, MD, PhD, director of the COOL Lab, is a co-inventor of optical coherence tomography (OCT), which has become the most frequently used ophthalmic imaging procedure since 2003.   The COOL Lab has pioneered many advances in ophthalmic OCT.  In the anterior eye, COOL Lab researchers developed methods to map and measure the cornea, anterior chamber, angle, and lens and continues to lead the field in this area.  This technology is now widely used to diagnose early keratoconus, narrow-angle glaucoma, ocular surface tumors, plan phototherapeutic keratectomy (PTK), and calculate intraocular lens power in patients with previous LASIK or other keratorefractive surgery. In the posterior segment, COOL Lab led the multi-center Advanced Imaging for Glaucoma bioengineering partnership,  

which was responsible for developing ganglion cell complex mapping for glaucoma evaluation, Doppler OCT to measure total retinal blood flow, and the first clinical investigation using OCT angiography.   COOL Lab researchers developed a very efficient OCT angiography algorithm called “split-spectrum amplitude decorrelation angiography” (SSADA), which made the first commercial clinical OCT angiography system possible. COOL Lab researchers are actively improving OCT angiography and applying it to the evaluation and management of age-related macular degeneration, diabetic retinopathy, inherited retinal degenerations, and ocular tumors.  On the treatment side, the COOL lab is investigating the optimal technique for combining corneal collagen crosslinking and PTK for the treatment of keratoconus and is developing a laser thermal conjunctivoplasty device provides a safe, gentle, and fast healing procedure to treat conjunctivochalasis in an ophthalmologist’s office.  The interdisciplinary team is able to perform interdisciplinary research from developing hardware (ultrahigh-speed OCT, laser surgical instrumentation), advancing signal and image processing algorithms, optimizing novel laser surgical techniques, conducting pilot clinical studies, to organizing large multi-site clinical studies.   The COOL Lab also supports the Casey Reading Center with advanced OCT and OCT angiography reading software that can be used in a wide variety of clinical studies in retinal and optic nerve diseases.

3375 SW Terwillinger Blvd

Portland, OR 97239

​Telephone : 503.494.5131

Email : coollab.ohsu@gmail.com

© 2018 Center for Ophthalmic Optics & Lasers
David Huang

Presenting at ARVO 2019