Welcome to the COOL lab at Oregon Health & Science University. We are dedicated to the advancement of biomedical imaging techniques in order to improve the diagnosis and treatment of eye diseases.

See the careers tab for opportunities at the COOL Lab!

The COOL Lab staff has found some fun ways to stay connected during COVID-19 modified operations!

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Congratulations to Shaohua Pi for receiving a Career-Starter Grant from Knights Templar Eye Foundation!

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Congratulations to Dr. Yali Jia on her election as a Fellow to the American Institute for Medical and Biological Engineering 

Yali Jia, Ph.D., has been elected as a Fellow, Class of 2021, by the American Institute for Medical and Biological Engineering. Dr. Jia was nominated, reviewed, and elected by peers and members of the College of Fellows for outstanding contributions to technical development and clinical translation of OCT, OCT angiography, and artificial intelligence management of eye diseases. Congratulations!

Congratulations to Keke Liu on his promotion to Full-Time Research Assistant!

Keke earned his BS in biomedical engineering at University of Miami. His research interests include OCT and OCTA imaging in glaucoma and retinal diseases.

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Congratulations Dr. David Huang for receiving the Greenberg Prize Award!

WASHINGTON, Dec. 3, 2020 /PRNewswire/ -- End Blindness 2020—an unprecedented joint effort by leading scientists and figures from the worlds of business, politics, culture, art, music and entertainment to rid the world of blindness—is about to mark a major milestone. On December 14, 2020, 13 pioneering scientists will share $3 million in prizes, from The Sanford and Sue Greenberg Prize to End Blindness, for their groundbreaking scientific and medical contributions to permanently and universally eradicate a condition that has plagued humans since the beginning of time. The hour-long streamed ceremony will be freely accessible and open to all at www.EndBlindness2020.com.

The Greenberg Prize awards ceremony will feature Art Garfunkel, Margaret Atwood, Al Gore, Michael Bloomberg, and Sen. Chris Coons among other luminaries. Musical performances will be provided by special guests. Grammy Award-winning jazz artist Diane Schuur, who was blind from birth due to Retinopathy of Prematurity, will share a few special words. Art-world legend Frank Stella will unveil a sculpture created in honor of the prize.

The Greenberg Prize ceremony will also feature a moving tribute to the late Ruth Bader Ginsburg, a longtime supporter of the End Blindness movement. The tribute will include exclusive footage of Justice Ginsburg reading from Hello Darkness, My Old Friend, the memoir of End Blindness 2020 co-founder Sanford D. Greenberg.

"While today's prize marks the culmination of years of challenging scientific work, in reality this prize is only the beginning of a journey of innovation and cooperation," Dr. Greenberg says. "Together, we are forging a new reality, one in which blindness will no longer determine the future of millions of people. We will end blindness, sooner than any of us can imagine, permanently and for everyone."

Recipients of The Greenberg Prize include members of the scientific and medical communities who have pioneered breathtaking advances in the fight to end the debilitating condition. Prize recipients are being honored in two categories: the Outstanding Achievement Prize, highlighting profound strides toward treating and curing blindness, and The Visionary Prize, providing funding for scientists whose research exhibits significant potential in ending this ancient scourge.

Outstanding Achievement Recipients:

  • Dr. Ravindran Ravilla, Aravind Eye Care System

  • Dr. G. N. Rao, The L.V. Prasad Eye Institute

  • Dr. Jean Bennett, Center for Advanced Retinal and Ocular Therapeutics, Department of Ophthalmology, Perelman School of Medicine at the University of Pennsylvania

  • Dr. Gustavo Aguirre, Division of Experimental Retinal Therapies, Department of Clinical Sciences & Advanced Medicine, School of Veterinary Medicine at the University of Pennsylvania

  • Dr. William Hauswirth, Department of Ophthalmology of the University of Florida

  • Dr. Albert Maguire, Center for Advanced Retinal and Ocular Therapeutics, Department of Ophthalmology, Perelman School of Medicine at the University of Pennsylvania

Visionary Recipients:

  • Dr. James Fujimoto, Department of Electrical Engineering and Computer Science Research Laboratory of Electronics, Massachusetts Institute of Technology

  • Dr. David Huang, Casey Eye Institute and Department of Ophthalmology, Oregon Health and Science University

  • Mr. Eric Swanson, Department of Electrical Engineering and Computer Science Research Laboratory of Electronics, Massachusetts Institute of Technology

  • Dr. Zhigang He, Boston Children's Hospital F.M. Kirby Neurobiology Center

  • Dr. Simon John, The Jackson Laboratory, Department of Ophthalmology, Columbia University

  • Dr. Botond Roska, Institute of Molecular and Clinical Ophthalmology Basel

  • Dr. Masayo Takahashi, RIKEN Center for Biosystems Dynamics Research; Vision Care, Inc. as part of Kobe Eye Center

"This is not just a prize but the 21st century equivalent of a moonshot, the effects of which will resound through history," according to Dr. Peter McDonnell, director of the Wilmer Eye Institute at the Johns Hopkins University School of Medicine and a member of the End Blindness National Governing Council. "Since time immemorial, blindness has been understood as an immutable fixture of the human condition. The great shift End Blindness has brought about demonstrates this is no longer the case. Together, we will end blindness—and sooner than anyone had ever imagined."

SOURCE The Greenberg Prize


Kevin Lathrop

Kevin is a research coordinator in the COOL Lab. He is currently working on the Diabetic retinopathy studies as well as assisting in the cornea and MS studies. He has experience in general ophthalmology since 2017. Prior to working in ophthalmology he has worked in optometry and was an optician. He collects data including OCT imaging and other ancillary testing from study patients. Kevin is interested in going to optometry school.


Yali Jia, PhD and John Morrison, MD Received NIH R01 Grant for visible-light OCT angiography, velocimetry, and oximetry for characterizing retinal vascular alterations in glaucoma (2020-2023)


This project will develop advanced technology to image retinal capillaries and measure capillary blood flow and oxygen content. This may provide an early indicator of glaucoma progression and help study a potential cause of increased susceptibility to intraocular pressure in glaucoma patients.

Future Vision Foundation selects Dr. David Huang for 2019 Future Vision award

Dr. Huang is the co-inventor of Optical Coherence Tomography (OCT), the most commonly used ophthalmic imaging technology at 30 million procedures per year. His seminal article on OTC has been cited over 13,000 times. Dr. Huang’s work is recognized as one of the most influential in the history of Ophthalmology.

David Huang ranked #1 inventor
by Ophthalmologist Magazine
Yali Jia wins 2019 Discovery
Award for Women in Science
Yali Jia wins ARVO 2019
Translational Research Award
David Huang
David Huang

Presenting at ARVO 2019

Yali Jia
Yali Jia

Yali Jia, PhD receiving award at ARVO 2019

Halloween 2019
Halloween 2019

Aliens and Astronauts

David Huang
David Huang

Presenting at ARVO 2019





The mission of the Center for Ophthalmic Optics and Lasers (COOL) is to conserve, improve and restore vision through advances in laser and optical technology.


The Center for Ophthalmic Optics and Lasers (COOL) at the Casey Eye Institute, Oregon Health & Science University is an interdisciplinary research center that focuses on improving the diagnosis and treatment of eye diseases through advances in laser and optical technology.  David Huang, MD, PhD, director of the COOL Lab, is a co-inventor of optical coherence tomography (OCT), which has become the most frequently used ophthalmic imaging procedure since 2003.   The COOL Lab has pioneered many advances in ophthalmic OCT.  In the anterior eye, COOL Lab researchers developed methods to map and measure the cornea, anterior chamber, angle, and lens and continues to lead the field in this area.  This technology is now widely used to diagnose early keratoconus, narrow-angle glaucoma, ocular surface tumors, plan phototherapeutic keratectomy (PTK), and calculate intraocular lens power in patients with previous LASIK or other keratorefractive surgery. In the posterior segment, COOL Lab led the multi-center Advanced Imaging for Glaucoma bioengineering partnership,  

which was responsible for developing ganglion cell complex mapping for glaucoma evaluation, Doppler OCT to measure total retinal blood flow, and the first clinical investigation using OCT angiography.   COOL Lab researchers developed a very efficient OCT angiography algorithm called “split-spectrum amplitude decorrelation angiography” (SSADA), which made the first commercial clinical OCT angiography system possible. COOL Lab researchers are actively improving OCT angiography and applying it to the evaluation and management of age-related macular degeneration, diabetic retinopathy, inherited retinal degenerations, and ocular tumors.  On the treatment side, the COOL lab is investigating the optimal technique for combining corneal collagen crosslinking and PTK for the treatment of keratoconus and is developing a laser thermal conjunctivoplasty device provides a safe, gentle, and fast healing procedure to treat conjunctivochalasis in an ophthalmologist’s office.  The interdisciplinary team is able to perform interdisciplinary research from developing hardware (ultrahigh-speed OCT, laser surgical instrumentation), advancing signal and image processing algorithms, optimizing novel laser surgical techniques, conducting pilot clinical studies, to organizing large multi-site clinical studies.   The COOL Lab also supports the Casey Reading Center with advanced OCT and OCT angiography reading software that can be used in a wide variety of clinical studies in retinal and optic nerve diseases.